Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sjögren's Syndrome
Sensory neuronopathy is described in association with the Sjögren's syndrome (SS). We studied a 55-year-old woman with a 4-year history of progressive asymmetric numbness, distal tingling, and burning sensation in upper and lower limbs. In a few months, she developed ataxia with increased hypoa...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/186320 |
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| author | Maria Giovanna Danieli Lucia Pettinari Ramona Morariu Fernando Monteforte Francesco Logullo |
| author_facet | Maria Giovanna Danieli Lucia Pettinari Ramona Morariu Fernando Monteforte Francesco Logullo |
| author_sort | Maria Giovanna Danieli |
| collection | DOAJ |
| description | Sensory neuronopathy is described in association with the Sjögren's syndrome (SS). We studied a 55-year-old woman with a 4-year history of progressive asymmetric numbness, distal tingling, and burning sensation in upper and lower limbs. In a few months, she developed ataxia with increased hypoanaesthesia. Electrodiagnostic tests revealed undetectable distal and proximal sensory nerve action potential in upper and lower limbs. Cervical spine magnetic resonance showed a signal hyperintensity of posterior columns. Previous treatment with high-dose glucocorticoids and azathioprine was ineffective. A combined treatment with intravenous immunoglobulin and mycophenolate mofetil was followed by a progressive and persistent improvement. This case documented the efficacy and the safety of the coadministration of intravenous immunoglobulin and mycophenolate mofetil in sensory neuronopathy associated with SS refractory to conventional immunosuppressive therapy. |
| format | Article |
| id | doaj-art-a0ab34ef487841c8a8affd278d0debb8 |
| institution | Kabale University |
| issn | 2090-6609 2090-6617 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Immunology |
| spelling | doaj-art-a0ab34ef487841c8a8affd278d0debb82025-02-03T01:03:46ZengWileyCase Reports in Immunology2090-66092090-66172012-01-01201210.1155/2012/186320186320Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sjögren's SyndromeMaria Giovanna Danieli0Lucia Pettinari1Ramona Morariu2Fernando Monteforte3Francesco Logullo4Clinica Medica, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche & Ospedali Riuniti, Via Tronto 10, 60126 Ancona, ItalyU.O. di Medicina-LPA, Presidio di Loreto, 66025 Loreto, ItalyClinica Medica, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche & Ospedali Riuniti, Via Tronto 10, 60126 Ancona, ItalyU.O. di Radiodiagnostica, Ospedale di Casarano, 73042 Lecce, ItalyClinica Neurologica, Dipartimento di Medicina Sperimentale e Clinica, Polo Didattico Scientifico, Università Politecnica delle Marche & Azienda Ospedali Riuniti, Via Tronto 10, 60126 Ancona, ItalySensory neuronopathy is described in association with the Sjögren's syndrome (SS). We studied a 55-year-old woman with a 4-year history of progressive asymmetric numbness, distal tingling, and burning sensation in upper and lower limbs. In a few months, she developed ataxia with increased hypoanaesthesia. Electrodiagnostic tests revealed undetectable distal and proximal sensory nerve action potential in upper and lower limbs. Cervical spine magnetic resonance showed a signal hyperintensity of posterior columns. Previous treatment with high-dose glucocorticoids and azathioprine was ineffective. A combined treatment with intravenous immunoglobulin and mycophenolate mofetil was followed by a progressive and persistent improvement. This case documented the efficacy and the safety of the coadministration of intravenous immunoglobulin and mycophenolate mofetil in sensory neuronopathy associated with SS refractory to conventional immunosuppressive therapy.http://dx.doi.org/10.1155/2012/186320 |
| spellingShingle | Maria Giovanna Danieli Lucia Pettinari Ramona Morariu Fernando Monteforte Francesco Logullo Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sjögren's Syndrome Case Reports in Immunology |
| title | Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sjögren's Syndrome |
| title_full | Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sjögren's Syndrome |
| title_fullStr | Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sjögren's Syndrome |
| title_full_unstemmed | Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sjögren's Syndrome |
| title_short | Intravenous Immunoglobulin and Mycophenolate Mofetil for Long-Standing Sensory Neuronopathy in Sjögren's Syndrome |
| title_sort | intravenous immunoglobulin and mycophenolate mofetil for long standing sensory neuronopathy in sjogren s syndrome |
| url | http://dx.doi.org/10.1155/2012/186320 |
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