Data- and knowledge-derived functional landscape of human solute carriers

Data- and knowledge-derived functional landscape of human solute carriers

Abstract The human solute carrier (SLC) superfamily of ~460 membrane transporters remains the largest understudied protein family despite its therapeutic potential. To advance SLC research, we developed a comprehensive knowledgebase that integrates systematic multi-omics data sets with selected cura...

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Main Authors: Ulrich Goldmann, Tabea Wiedmer, Andrea Garofoli, Vitaly Sedlyarov, Manuel Bichler, Ben Haladik, Gernot Wolf, Eirini Christodoulaki, Alvaro Ingles-Prieto, Evandro Ferrada, Fabian Frommelt, Shao Thing Teoh, Philipp Leippe, Gabriel Onea, Martin Pfeifer, Mariah Kohlbrenner, Lena Chang, Paul Selzer, Jürgen Reinhardt, Daniela Digles, Gerhard F Ecker, Tanja Osthushenrich, Aidan MacNamara, Anders Malarstig, David Hepworth, Giulio Superti-Furga
Format: Article
Language:English
Published: Springer Nature 2025-05-01
Series:Molecular Systems Biology
Subjects:
Human Gene Function
Knowledgebase
Membrane Transporters
Multimodal Data Integration
Solute Carriers
Online Access:https://doi.org/10.1038/s44320-025-00108-2
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https://doi.org/10.1038/s44320-025-00108-2

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