A Novel Platform Featuring Nanomagnetic Ligand Fishing Based on Fixed-Orientation Immobilized Magnetic Beads for Screening Potential Cyclooxygenase-2 Inhibitors from <i>Panax notoginseng</i> Leaves

A Novel Platform Featuring Nanomagnetic Ligand Fishing Based on Fixed-Orientation Immobilized Magnetic Beads for Screening Potential Cyclooxygenase-2 Inhibitors from <i>Panax notoginseng</i> Leaves

A novel screening platform based on an Fe<sub>3</sub>O<sub>4</sub>@C@PDA-Ni<sup>2+</sup>@COX-2 ligand fishing combination with high-performance liquid chromatography–mass spectrometry was first designed, synthesized, and employed to screen and identify COX-2 inhib...

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Bibliographic Details
Main Authors: Fan Zhang, Fan Sun, Lequan Yu, Fei Li, Lixia Liu, Xiaoyan Cao, Yi Zhang, Lijie Wu
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
ligand fishing
magnetic nanoparticles
immobilized enzymes
COX-2 inhibitors
<i>Panax notoginseng</i> leaves
Online Access:https://www.mdpi.com/1420-3049/29/23/5801
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