Metabolic expression profiling analysis reveals pyruvate-mediated EPHB2 upregulation promotes lymphatic metastasis in head and neck squamous cell carcinomas

Metabolic expression profiling analysis reveals pyruvate-mediated EPHB2 upregulation promotes lymphatic metastasis in head and neck squamous cell carcinomas

Abstract Lymphatic metastasis is a well-known factor for initiating distant metastasis of head and neck squamous cell carcinoma (HNSCC), which caused major death in most patients with cancer. Meanwhile, metabolic reprogramming to support metastasis is regarded as a prominent hallmark of cancers. How...

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Main Authors: Jingjing Miao, Boyu Chen, Lu Zhang, Zhongming Lu, Rui Wang, Chunyang Wang, Xingyu Jiang, Qi Shen, Yue Li, Dongni Shi, Ying Ouyang, Xiangfu Chen, Xiaowu Deng, Siyi Zhang, Hequn Zou, Shuwei Chen
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Head and neck squamous cell carcinoma
Lymphatic metastasis
Pyruvate metabolism
EPHB2
Lymphangiogenesis
Online Access:https://doi.org/10.1186/s12967-025-06305-9
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https://doi.org/10.1186/s12967-025-06305-9

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