3D periodic microscale structures on binary copper-nickel alloys via fs-DLIP: impact on E. coli-substrate interaction
In response to the rise of multidrug-resistant infections, researchers are increasingly focusing on modifying material surfaces through chemical or topographical changes to limit microbial spread. Copper and its alloys are particularly valued for their antimicrobial properties, playing a key role in...
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Elsevier
2025-10-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127525009657 |
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| author | Aisha Saddiqa Ahmed Sebastian Wältermann Pablo María Delfino Daniel Wyn Müller Jean–Nicolas Audinot Jean-François Pierson Frank Mücklich |
| author_facet | Aisha Saddiqa Ahmed Sebastian Wältermann Pablo María Delfino Daniel Wyn Müller Jean–Nicolas Audinot Jean-François Pierson Frank Mücklich |
| author_sort | Aisha Saddiqa Ahmed |
| collection | DOAJ |
| description | In response to the rise of multidrug-resistant infections, researchers are increasingly focusing on modifying material surfaces through chemical or topographical changes to limit microbial spread. Copper and its alloys are particularly valued for their antimicrobial properties, playing a key role in combating pathogen transmission. To explore the potential of enhancing the antibacterial performance of copper-based alloys, this study focuses on surface modification of binary copper-nickel alloys. The goal is to create periodic microstructures at the scale of a single bacterial cell (Escherichia coli) and explore the bacteria-substrate interaction. Two copper-nickel alloy compositions with 10 and 30 wt-% nickel are selected to assess the impact of nickel on laser-material interaction. Additionally, two surface structures, lines and honeycomb, are fabricated to evaluate how structure type affects bacterial interaction. Results show that the line-like structures on the 10 wt-% nickel alloy enhance bacterial killing, while honeycomb structures show no improvement. Conversely, both laser-structured copper-nickel alloys with 30 wt-% nickel exhibit decreased bacterial killing, attributed to the reduced surface copper concentration (below 60 wt-%) as confirmed by chemical analyses. These findings highlight the importance of copper content and structural compatibility for effective contact-killing performance. |
| format | Article |
| id | doaj-art-a055b437b4fc471c82d82d7f662bee99 |
| institution | Kabale University |
| issn | 0264-1275 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj-art-a055b437b4fc471c82d82d7f662bee992025-08-20T03:41:44ZengElsevierMaterials & Design0264-12752025-10-0125811454510.1016/j.matdes.2025.1145453D periodic microscale structures on binary copper-nickel alloys via fs-DLIP: impact on E. coli-substrate interactionAisha Saddiqa Ahmed0Sebastian Wältermann1Pablo María Delfino2Daniel Wyn Müller3Jean–Nicolas Audinot4Jean-François Pierson5Frank Mücklich6Functional Materials, Saarland University, 66123 Saarbrücken, Germany; Université de Lorraine, CNRS, IJL F-54000 Nancy, France; Corresponding author at: Functional Materials, Saarland University, 66123 Saarbrücken, Germany.Functional Materials, Saarland University, 66123 Saarbrücken, GermanyAdvanced Instrumentation for Nano-Analytics (AINA), Luxembourg Institute of Science and Technology (LIST), L-4422 Belvaux, Luxembourg; University of Luxembourg, 4365 Esch-sur-Alzette, LuxembourgFunctional Materials, Saarland University, 66123 Saarbrücken, GermanyAdvanced Instrumentation for Nano-Analytics (AINA), Luxembourg Institute of Science and Technology (LIST), L-4422 Belvaux, LuxembourgUniversité de Lorraine, CNRS, IJL F-54000 Nancy, FranceFunctional Materials, Saarland University, 66123 Saarbrücken, GermanyIn response to the rise of multidrug-resistant infections, researchers are increasingly focusing on modifying material surfaces through chemical or topographical changes to limit microbial spread. Copper and its alloys are particularly valued for their antimicrobial properties, playing a key role in combating pathogen transmission. To explore the potential of enhancing the antibacterial performance of copper-based alloys, this study focuses on surface modification of binary copper-nickel alloys. The goal is to create periodic microstructures at the scale of a single bacterial cell (Escherichia coli) and explore the bacteria-substrate interaction. Two copper-nickel alloy compositions with 10 and 30 wt-% nickel are selected to assess the impact of nickel on laser-material interaction. Additionally, two surface structures, lines and honeycomb, are fabricated to evaluate how structure type affects bacterial interaction. Results show that the line-like structures on the 10 wt-% nickel alloy enhance bacterial killing, while honeycomb structures show no improvement. Conversely, both laser-structured copper-nickel alloys with 30 wt-% nickel exhibit decreased bacterial killing, attributed to the reduced surface copper concentration (below 60 wt-%) as confirmed by chemical analyses. These findings highlight the importance of copper content and structural compatibility for effective contact-killing performance.http://www.sciencedirect.com/science/article/pii/S0264127525009657FemtosecondDirect laser interference patterningCopper-nickel alloyAntibacterialPeriodic three-dimensional structuresLine-like structures |
| spellingShingle | Aisha Saddiqa Ahmed Sebastian Wältermann Pablo María Delfino Daniel Wyn Müller Jean–Nicolas Audinot Jean-François Pierson Frank Mücklich 3D periodic microscale structures on binary copper-nickel alloys via fs-DLIP: impact on E. coli-substrate interaction Materials & Design Femtosecond Direct laser interference patterning Copper-nickel alloy Antibacterial Periodic three-dimensional structures Line-like structures |
| title | 3D periodic microscale structures on binary copper-nickel alloys via fs-DLIP: impact on E. coli-substrate interaction |
| title_full | 3D periodic microscale structures on binary copper-nickel alloys via fs-DLIP: impact on E. coli-substrate interaction |
| title_fullStr | 3D periodic microscale structures on binary copper-nickel alloys via fs-DLIP: impact on E. coli-substrate interaction |
| title_full_unstemmed | 3D periodic microscale structures on binary copper-nickel alloys via fs-DLIP: impact on E. coli-substrate interaction |
| title_short | 3D periodic microscale structures on binary copper-nickel alloys via fs-DLIP: impact on E. coli-substrate interaction |
| title_sort | 3d periodic microscale structures on binary copper nickel alloys via fs dlip impact on e coli substrate interaction |
| topic | Femtosecond Direct laser interference patterning Copper-nickel alloy Antibacterial Periodic three-dimensional structures Line-like structures |
| url | http://www.sciencedirect.com/science/article/pii/S0264127525009657 |
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