Sex-Specific Adaptations in Alzheimer’s Disease and Ischemic Stroke: A Longitudinal Study in Male and Female APP<sub>swe</sub>/PS1<sub>dE9</sub> Mice

Sex-Specific Adaptations in Alzheimer’s Disease and Ischemic Stroke: A Longitudinal Study in Male and Female APP<sub>swe</sub>/PS1<sub>dE9</sub> Mice

The long-term impact of stroke on Alzheimer’s disease (AD) progression, particularly regarding sex-specific differences, remains unknown. Using a longitudinal study design, we investigated transient middle cerebral artery occlusion in 3.5-month-old APP<sub>swe</sub>/PS1<sub>dE9<...

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Main Authors: Klara J. Lohkamp, Nienke Timmer, Gemma Solé Guardia, Justin Shenk, Vivienne Verweij, Bram Geenen, Pieter J. Dederen, Lieke Bakker, Cansu Egitimci, Rengin Yoldas, Minou Verhaeg, Josine Kothuis, Desirée Nieuwenhuis, Maximilian Wiesmann, Amanda J. Kiliaan
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Life
Subjects:
Alzheimer’s disease
stroke
sex differences
MRI
cerebral blood flow
cognition neuroinflammation
Online Access:https://www.mdpi.com/2075-1729/15/3/333
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