Analysis of six CYP450 genetic variants regarding the response to cannabidiol combined with anticonvulsant medication in mexican patients with drug-resistant epilepsy

Analysis of six CYP450 genetic variants regarding the response to cannabidiol combined with anticonvulsant medication in mexican patients with drug-resistant epilepsy

BackgroundCannabidiol (CBD) reduces the frequency of seizures in individuals with specific epileptic syndromes, but its effectiveness for other types of drug-resistant epilepsy (DRE) is unclear. CYP450 enzymes primarily metabolize CBD. The aim of this study was to identify CYP450 genotypes regarding...

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Bibliographic Details
Main Authors: Iris A. Feria-Romero, Luisa Rocha, Araceli Reyes-Cuayahuitl, Iris Martínez-Juárez, Daniel San-Juan, Consuelo Escamilla-Nuñez, Sandra Orozco-Suarez
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
pharmacoresistant epilepsy
cannabidiol treatment
CYPs
SNP
antiseizure medication
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1626054/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1626054/full

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