Tyrosine bioconjugation using stably preparable urazole radicals

Tyrosine bioconjugation using stably preparable urazole radicals

Our ex situ tyrosine bioconjugation method utilizes the oxidation of N-methylurazole by Bobbitt's salt or electrochemical activation to generate stable radicals for selective tyrosine labeling, thereby addressing the longstanding challenges in protein bioconjugation. Unlike traditional tyrosine...

Full description

Saved in:
Bibliographic Details
Main Authors: Shinichi Sato, Shogo Miyano, Keita Nakane, Zhengyi Liu, Munehiro Kumashiro, Tomohide Saio, Yuya Tanaka, Akira Shigenaga, Chizu Fujimura, Eri Koyanagi, Hafumi Nishi, Shusuke Tomoshige, Minoru Ishikawa
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Tetrahedron Chem
Subjects:
Tyrosine
Bioconjugation
Radicals
Protein chemical labeling
Chemical proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2666951X24000500
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2666951X24000500

Similar Items