Lateral habenula-rostromedial tegmental nucleus circuit mediates inflammatory pain in mice

Lateral habenula-rostromedial tegmental nucleus circuit mediates inflammatory pain in mice

Abstract Background The monoamine system, particularly the serotonergic neurons in the dorsal raphe nucleus (DRN), associated with the synthesis and release of 5-hydroxytryptamine, is crucial for regulating pain. The lateral habenula (LHb) modulates DRN neurons by acting through GABAergic neurons lo...

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Main Authors: Yanfei Sun, Jing Cao, Chunpeng Xu, Jiangtao Sun, Xiaofeng Liu, Zhenguang Shi, SiMeng An, Danyang Zhao, Dongjie Sun, Xuxin Wang, Guoyan Zhao, Chi Zhang, Guangjian Li, Jinyu Xiao, Jing Yang, Hua Zhao
Format: Article
Language:English
Published: BMC 2025-05-01
Series:The Journal of Headache and Pain
Subjects:
Lateral habenula
Rostromedial tegmental nucleus
Dorsal raphe nucleus
Glutamatergic neurons
Pain
Neural pathway
Online Access:https://doi.org/10.1186/s10194-025-02052-w
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https://doi.org/10.1186/s10194-025-02052-w

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