Mannose receptor‐derived peptides neutralize pore‐forming toxins and reduce inflammation and development of pneumococcal disease

Mannose receptor‐derived peptides neutralize pore‐forming toxins and reduce inflammation and development of pneumococcal disease

Abstract Cholesterol‐dependent cytolysins (CDCs) are essential virulence factors for many human pathogens like Streptococcus pneumoniae (pneumolysin, PLY), Streptococcus pyogenes (streptolysin O, SLO), and Listeria monocytogenes (Listeriolysin, LLO) and induce cytolysis and inflammation. Recently, w...

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Main Authors: Karthik Subramanian, Federico Iovino, Vasiliki Tsikourkitoudi, Padryk Merkl, Sultan Ahmed, Samuel B Berry, Marie‐Stephanie Aschtgen, Mattias Svensson, Peter Bergman, Georgios A Sotiriou, Birgitta Henriques‐Normark
Format: Article
Language:English
Published: Springer Nature 2020-09-01
Series:EMBO Molecular Medicine
Subjects:
calcium phosphate nanoparticles
mannose receptor C type 1
pore‐forming toxins
Streptococcus pneumoniae
toxin inhibitory peptides
Online Access:https://doi.org/10.15252/emmm.202012695
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https://doi.org/10.15252/emmm.202012695

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