Methadone-Induced Toxicity—An Unexpected Challenge for the Brain and Heart in ICU Settings: Case Report and Review of the Literature

Methadone-Induced Toxicity—An Unexpected Challenge for the Brain and Heart in ICU Settings: Case Report and Review of the Literature

Introduction: Methadone, a synthetic opioid used for opioid substitution therapy (OST), is typically associated with arrhythmias rather than direct myocardial depression. Neurological complications, especially with concurrent antipsychotic use, have also been reported. Acute left ventricular failure...

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Bibliographic Details
Main Authors: Buzatu Georgiana Cristina, Sebastian Isac, Geani-Danut Teodorescu, Teodora Isac, Cristina Martac, Cristian Cobilinschi, Bogdan Pavel, Cristina Veronica Andreescu, Gabriela Droc
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Life
Subjects:
methadone
opioid substitution therapy
left ventricular failure
cardiogenic shock
brain insult
multidisciplinary care
Online Access:https://www.mdpi.com/2075-1729/15/7/1084
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