SPI1 upregulated LILRB2 to enhance the immunosuppressive phenotype of LPS-tolerant macrophages by inhibiting TLR8-mediated MyD88/NF-κB signaling

SPI1 upregulated LILRB2 to enhance the immunosuppressive phenotype of LPS-tolerant macrophages by inhibiting TLR8-mediated MyD88/NF-κB signaling

Abstract In sepsis, immunosuppression is commonly observed as lipopolysaccharide (LPS) tolerance in macrophages. Leukocyte immunoglobulin-like receptor B2 (LILRB2) is an inhibitory receptor on immune cells that may play a crucial role in the immunosuppressive phenotype of LPS-tolerant macrophages, a...

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Bibliographic Details
Main Authors: Ruojing Bai, Jun Guo
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Biology Direct
Subjects:
LILRB2
SPI1
Sepsis
LPS-tolerant macrophages
Immunosuppressive phenotype
MyD88/NF-κB signaling
Online Access:https://doi.org/10.1186/s13062-025-00669-0
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https://doi.org/10.1186/s13062-025-00669-0

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