Early-life obesogenic environment integrates immunometabolic and epigenetic signatures governing neuroinflammation

Early-life obesogenic environment integrates immunometabolic and epigenetic signatures governing neuroinflammation

Childhood overweight/obesity is associated with stress-related psychopathology, yet the pathways connecting childhood obesity to stress susceptibility are poorly understood. We employed a systems biology approach with 62 adolescent Lewis rats fed a Western-like high-saturated fat diet (WD, 41% kcal...

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Main Authors: Perla Ontiveros-Ángel, Julio David Vega-Torres, Timothy B. Simon, Vivianna Williams, Yaritza Inostroza-Nives, Nashareth Alvarado-Crespo, Yarimar Vega Gonzalez, Marjory Pompolius, William Katzka, John Lou, Fransua Sharafeddin, Ike De la Peña, Tien Dong, Arpana Gupta, Chi T. Viet, Marcelo Febo, Andre Obenaus, Aarti Nair, Johnny D. Figueroa
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Adolescence
Anxiety
Obesity
Microbiome
Microglia
Neuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354624001571
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