PPE50 variants as novel phylogeographic signatures of host-pathogen co-evolution in tuberculosis
PPE50 is a diverse novel subfamily of PE/PPE proteins in the Mycobacterium tuberculosis complex that show a phylogeographic distribution indicative host-pathogen co-evolution.
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08383-3 |
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| author | Christopher D’Souza Jody E. Phelan Paula-Josefina Gomez-Gonzalez Joseph Thorpe Taane G. Clark Anthony G. Tsolaki |
| author_facet | Christopher D’Souza Jody E. Phelan Paula-Josefina Gomez-Gonzalez Joseph Thorpe Taane G. Clark Anthony G. Tsolaki |
| author_sort | Christopher D’Souza |
| collection | DOAJ |
| description | PPE50 is a diverse novel subfamily of PE/PPE proteins in the Mycobacterium tuberculosis complex that show a phylogeographic distribution indicative host-pathogen co-evolution. |
| format | Article |
| id | doaj-art-9fe848821aba4f1db6a5d9a1419a4d94 |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-9fe848821aba4f1db6a5d9a1419a4d942025-08-20T03:43:21ZengNature PortfolioCommunications Biology2399-36422025-07-018111210.1038/s42003-025-08383-3PPE50 variants as novel phylogeographic signatures of host-pathogen co-evolution in tuberculosisChristopher D’Souza0Jody E. Phelan1Paula-Josefina Gomez-Gonzalez2Joseph Thorpe3Taane G. Clark4Anthony G. Tsolaki5Department of Biosciences, College of Health, Medicine and Life Sciences, Brunel University of LondonLondon School of Hygiene and Tropical MedicineLondon School of Hygiene and Tropical MedicineLondon School of Hygiene and Tropical MedicineLondon School of Hygiene and Tropical MedicineDepartment of Biosciences, College of Health, Medicine and Life Sciences, Brunel University of LondonPPE50 is a diverse novel subfamily of PE/PPE proteins in the Mycobacterium tuberculosis complex that show a phylogeographic distribution indicative host-pathogen co-evolution.https://doi.org/10.1038/s42003-025-08383-3 |
| spellingShingle | Christopher D’Souza Jody E. Phelan Paula-Josefina Gomez-Gonzalez Joseph Thorpe Taane G. Clark Anthony G. Tsolaki PPE50 variants as novel phylogeographic signatures of host-pathogen co-evolution in tuberculosis Communications Biology |
| title | PPE50 variants as novel phylogeographic signatures of host-pathogen co-evolution in tuberculosis |
| title_full | PPE50 variants as novel phylogeographic signatures of host-pathogen co-evolution in tuberculosis |
| title_fullStr | PPE50 variants as novel phylogeographic signatures of host-pathogen co-evolution in tuberculosis |
| title_full_unstemmed | PPE50 variants as novel phylogeographic signatures of host-pathogen co-evolution in tuberculosis |
| title_short | PPE50 variants as novel phylogeographic signatures of host-pathogen co-evolution in tuberculosis |
| title_sort | ppe50 variants as novel phylogeographic signatures of host pathogen co evolution in tuberculosis |
| url | https://doi.org/10.1038/s42003-025-08383-3 |
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