Development of an enantioselective three-dimensional HPLC system for the determination of alanine, valine, isoleucine, allo-isoleucine and leucine in human plasma and urine

A three-dimensional (3D) HPLC system was designed/developed for the discriminative determination of aliphatic chiral amino acids, namely, alanine (Ala), valine (Val), isoleucine (Ile), allo-Ile (aIle) and leucine (Leu), in human physiological fluids. These aliphatic amino acid enantiomers are expect...

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Bibliographic Details
Main Authors: Yuri Nagata, Takeyuki Akita, Chiharu Ishii, Mai Oyaide, Masashi Mita, Tomomi Ide, Kenji Hamase
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Pharmaceutical and Biomedical Analysis Open
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Online Access:http://www.sciencedirect.com/science/article/pii/S2949771X23000130
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