Vinylogous functionalization of 4-alkylidene-5-aminopyrazoles with methyl trifluoropyruvates

Vinylogous functionalization of 4-alkylidene-5-aminopyrazoles with methyl trifluoropyruvates

A valuable vinylogous addition reaction between 4-alkylidene-5-aminopyrazoles and alkyl trifluoropyruvates leading to highly functionalized tertiary alcohols bearing a trifluoromethyl group and a pyrazole ring is presented. The corresponding trifluoromethyl alcohols are obtained in moderate to good...

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Bibliographic Details
Main Authors: Judit Hostalet-Romero, Laura Carceller-Ferrer, Gonzalo Blay, Amparo Sanz-Marco, José R. Pedro, Carlos Vila
Format: Article
Language:English
Published: Beilstein-Institut 2025-03-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
alcohols
diastereoselectivity
nitrogen heterocycles
pyrazoles
vinylogous reaction
Online Access:https://doi.org/10.3762/bjoc.21.41
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https://doi.org/10.3762/bjoc.21.41

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