Placenta-derived factors contribute to human iPSC-liver organoid growth

Placenta-derived factors contribute to human iPSC-liver organoid growth

Abstract Organoids derived from human induced pluripotent stem cells (hiPSC) are potentially applicable for regenerative medicine. However, the applications have been hampered by limited organoid size and function as a consequence of a lack of progenitor expansion. Here, we report the recapitulation...

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Main Authors: Yoshiki Kuse, Shinya Matsumoto, Syusaku Tsuzuki, Erica Carolina, Takashi Okumura, Toshiharu Kasai, Soichiro Yamabe, Kiyoshi Yamaguchi, Yoichi Furukawa, Tomomi Tadokoro, Yasuharu Ueno, Takayoshi Oba, Naoki Tanimizu, Hideki Taniguchi
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57551-w
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https://doi.org/10.1038/s41467-025-57551-w

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