Dual-enzyme activated theranostic nanoparticles for image-guided glioblastoma therapy

Dual-enzyme activated theranostic nanoparticles for image-guided glioblastoma therapy

Abstract Matrix metalloproteinase-14 (MMP-14) and Cathepsin-B (Cat-B) are overexpressed in glioblastoma (GBM) and not normal brain, making them promising targets for prodrug activation. We investigated a novel combination therapy using two tumor-enzyme activatable theranostic nanoprobes (TNP): TNP-M...

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Main Authors: Zahra Shokri Varniab, Edwin Chang, Jie Wang, Ramesh Duwa, Vidyani Suryadevara, Wei Wu, Manoj Kumar, Tie Liang, Zubeda Khatoon, Goreti Ribeiro Morais, Robert Falconer, Yifeng Shi, Grigory Tikhomirov, Kerem Nernekli, Laura Jean Pisani, Heike Elisabeth Daldrup-Link
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Glioblastoma
Theranostic
Nanoparticles
MRI
Ferumoxytol
Online Access:https://doi.org/10.1038/s41598-025-97775-w
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https://doi.org/10.1038/s41598-025-97775-w

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