Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma

Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma

Abstract Osteosarcoma (OS) is the most common primary bone malignancy. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) has been implicated in bone destruction, tumor survival and metastases during OS. We examined the role of Dkk-1 in OS disease progression and explored strategies for targeting its ac...

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Bibliographic Details
Main Authors: Andrew Haskell, Simin Pan, Robert Reese, Anthony Powers, Megan G. Lopez, Sebastian Lomeli, Christopher Story, Joshua Benton, J. Chris Blazier, Roland Kaunas, Carl A. Gregory
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Osteosarcoma
Dickkopf-1
Wnt
Antisense morpholino
Online Access:https://doi.org/10.1038/s41598-024-84037-4
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https://doi.org/10.1038/s41598-024-84037-4

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