Enhancing antitumor efficacy of oncolytic virus M1 via albendazole-sustained CD8+ T cell activation

Enhancing antitumor efficacy of oncolytic virus M1 via albendazole-sustained CD8+ T cell activation

The immune response plays a crucial role in the functionality of oncolytic viruses. In this study, Albendazole, an antihelminthic drug known to modulate the immune checkpoint PD-L1, was combined with the oncolytic virus M1 (OVM1) to treat mice with either prostate cancer (RM-1) or glioma (GL261) tum...

Full description

Saved in:
Bibliographic Details
Main Authors: Wenjing Bai, Xia Tang, Tong Xiao, Yangyang Qiao, Xuyan Tian, Bo Zhu, Jiehong Chen, Chaoxin Chen, Yuanyuan Li, Xueying Lin, Jing Cai, Yuan Lin, Wenbo Zhu, Guangmei Yan, Jiankai Liang, Jun Hu
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Oncology
Subjects:
oncolytic virus
albendazole
CD8+T
anti-tumor
CTLA4
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000559
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2950329924000559

Similar Items