Bioinformatics-based identification of key genes for Olaparib resistance in breast cancer: prognostic implications and therapeutic relevance

Bioinformatics-based identification of key genes for Olaparib resistance in breast cancer: prognostic implications and therapeutic relevance

Abstract Breast cancer is the most common malignancy among women worldwide, with drug therapy playing a crucial role in its treatment. In recent years, poly ADP-ribose polymerase (PARP) inhibitors, such as Olaparib, have shown significant efficacy in the management of BReast CAncer gene (BRCA)-mutat...

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Bibliographic Details
Main Authors: Kezhen Shen, Xiaozhe Li, Sihan Zhao, Xinyu Zhang, Le Yu, Jun Li, Lei Cai
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Discover Oncology
Subjects:
Breast cancer
Olaparib
Poly ADP-ribose polymerase inhibitor
Drug resistance
Genes
Online Access:https://doi.org/10.1007/s12672-025-02989-z
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https://doi.org/10.1007/s12672-025-02989-z

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