Toxicity mechanism analysis of cGAS-STING-TBK1 signaling pathway small molecule modulator based on network toxicology and molecular docking strategy: quinacrine acetate as an example

Toxicity mechanism analysis of cGAS-STING-TBK1 signaling pathway small molecule modulator based on network toxicology and molecular docking strategy: quinacrine acetate as an example

ObjectiveThis study aims to investigate the toxicity characteristics and mechanisms of quinacrine acetate, a small molecule modulator of the cGAS-STING-TBK1 signaling pathway, and to establish and validate the application value of network toxicology analysis strategy.MethodsProTox and ADMETlab platf...

Full description

Saved in:
Bibliographic Details
Main Authors: Jinchao Zhu, Qingyuan Lin, Honglin Zhu, Siqi Xie, Shengdong Nie
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Chemistry
Subjects:
quinacrine acetate
network toxicology
molecular docking
cGAS-STING-TBK1
respiratory toxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1584588/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2025.1584588/full

Similar Items