SpaIM: single-cell spatial transcriptomics imputation via style transfer

Abstract Spatial transcriptomics (ST) technologies have transformed our understanding of cellular organization but are limited by sparse signals and restricted gene coverage. To address these challenges, we introduce SpaIM, a style transfer learning model that leverages single-cell RNA sequencing (s...

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Bibliographic Details
Main Authors: Bo Li, Ziyang Tang, Aishwarya Budhkar, Xiang Liu, Tonglin Zhang, Baijian Yang, Jing Su, Qianqian Song
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63185-9
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