Synthesis of cross-linked carboxymethyl cellulose and poly (2-acrylamido-2-methylpropane sulfonic acid) hydrogel for sustained drug release optimized by Box-Behnken Design

Synthesis of cross-linked carboxymethyl cellulose and poly (2-acrylamido-2-methylpropane sulfonic acid) hydrogel for sustained drug release optimized by Box-Behnken Design

This research aims to fabricate and characterize chemically crosslinked CMC/PVP-co-poly (AMPS) based hydrogel for the sustained release of model drug metoprolol tartrate through the free radical polymerization technique. Box-Behnken Design was used to optimize CMC/PVP-co-poly (AMPS) hydrogel by vary...

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Bibliographic Details
Main Authors: Akram Ashames, Fahad Pervaiz, Moawia Al-Tabakha, Kanza Khalid, Nageeb Hassan, Hina Shoukat, Manal Buabeid, Ghulam Murtaza
Format: Article
Language:English
Published: Springer 2022-11-01
Series:Journal of Saudi Chemical Society
Subjects:
Hydrogels
Carboxymethyl cellulose
2-Acrylamdio-2-methylpropane sulphonic acid
Sustained release
Metoprolol
Antihypertensive
Online Access:http://www.sciencedirect.com/science/article/pii/S1319610322001235
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