Saccharin disrupts bacterial cell envelope stability and interferes with DNA replication dynamics

Saccharin disrupts bacterial cell envelope stability and interferes with DNA replication dynamics

Abstract Saccharin has been part of the human diet for over 100 years, and there is a comprehensive body of evidence demonstrating that it can influence the gut microbiome, ultimately impacting human health. However, the precise mechanisms through which saccharin can impact bacteria have remained el...

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Main Authors: Rubén de Dios, Kavita Gadar, Chris R Proctor, Evgenia Maslova, Jie Han, Mohamed A N Soliman, Dominika Krawiel, Emma L Dunbar, Bhupender Singh, Stelinda Peros, Tom Killelea, Anna-Luisa Warnke, Marius M Haugland, Edward L Bolt, Christian S Lentz, Christian J Rudolph, Ronan R McCarthy
Format: Article
Language:English
Published: Springer Nature 2025-04-01
Series:EMBO Molecular Medicine
Subjects:
Artificial Sweetener
Acinetobacter baumannii
Antimicrobial
Biofilm
DNA Replication
Online Access:https://doi.org/10.1038/s44321-025-00219-1
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https://doi.org/10.1038/s44321-025-00219-1

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