AK4 promotes nasopharyngeal carcinoma metastasis and chemoresistance by activating NLRP3 inflammatory complex
Abstract Metastasis is the main cause of treatment failure in nasopharyngeal carcinoma (NPC). Our previous study developed a transcriptomics-based gene signature (AK4, CPAMD8, DDAH1, and CRTR1) to predict metastasis in NPC and identify candidates that could benefit from induction chemotherapy (IC)....
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| Main Authors: | Sai-Lan Liu, Li Yuan, Xue-Song Sun, Bei-Bei Xiao, Kai-Qi Lan, Zi-Jian Lu, Da-Feng Lin, Xiao-Yun Li, Jin-Jie Yan, Shu-Mei Yan, Qiu-Yan Chen, Lin-Quan Tang, Hai-Qiang Mai |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-07-01
|
| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-025-07805-8 |
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