AK4 promotes nasopharyngeal carcinoma metastasis and chemoresistance by activating NLRP3 inflammatory complex

Abstract Metastasis is the main cause of treatment failure in nasopharyngeal carcinoma (NPC). Our previous study developed a transcriptomics-based gene signature (AK4, CPAMD8, DDAH1, and CRTR1) to predict metastasis in NPC and identify candidates that could benefit from induction chemotherapy (IC)....

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Main Authors: Sai-Lan Liu, Li Yuan, Xue-Song Sun, Bei-Bei Xiao, Kai-Qi Lan, Zi-Jian Lu, Da-Feng Lin, Xiao-Yun Li, Jin-Jie Yan, Shu-Mei Yan, Qiu-Yan Chen, Lin-Quan Tang, Hai-Qiang Mai
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07805-8
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