Mitochondrial ROS inhibition prevents doxorubicin-induced breast cancer cell migration and invasion

Mitochondrial ROS inhibition prevents doxorubicin-induced breast cancer cell migration and invasion

Summary: For cancer patients, metastasis is a life-threatening event limiting therapeutic options. Molecularly, the metastatic phenotype can be conferred by mitochondrial reactive oxygen species (mtROS) generated upon metabolic stress. Mitochondrial damage can also trigger mtROS production, which is...

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Main Authors: Tania Capeloa, Justine A. Van de Velde, Erica Pranzini, Luigi Ippolito, Luca X. Zampieri, Morgane Tardy, Thibaut Vazeille, Alan Provito, Giovanna Carrà, Alfonso Scalera, Valéry L. Payen, Paolo E. Porporato, Pierre Sonveaux
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Therapeutic procedure
Molecular network
Cancer systems biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225012921
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http://www.sciencedirect.com/science/article/pii/S2589004225012921

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