Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes in C. elegans

Abstract Therapeutic use of tiny extracellular vesicles (EVs) requires understanding cargo loading mechanisms. Here, we use a modular proximity labeling approach to identify the cargo of ciliary EVs associated with the transient receptor potential channel polycystin-2 PKD-2 of C. elegans. Polycystin...

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Bibliographic Details
Main Authors: Inna A. Nikonorova, Elizabeth desRanleau, Katherine C. Jacobs, Josh Saul, Jonathon D. Walsh, Juan Wang, Maureen M. Barr
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57512-3
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