Sleep drive, not total sleep amount, increases seizure risk

Sleep drive, not total sleep amount, increases seizure risk

Abstract Sleep loss has been associated with increased seizure risk since antiquity. Using automated video detection of spontaneous seizures in Drosophila epilepsy models, we show that seizures worsen only when sleep restriction raises homeostatic “sleep drive,” not simply when total sleep amount fa...

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Main Authors: Vishnu Anand Cuddapah, Cynthia T. Hsu, Fernanda Valle Sirias, Yongjun Li, Hrishit M. Shah, Christopher Saul, Samantha Killiany, Camilo Guevara, Joy Shon, Zhifeng Yue, Gabrielle L. Gionet, Mary E. Putt, Amita Sehgal
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62311-x
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https://doi.org/10.1038/s41467-025-62311-x

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