Monocyte-lineage tumor infiltration predicts immunoradiotherapy response in advanced pretreated soft-tissue sarcoma: phase 2 trial results

Monocyte-lineage tumor infiltration predicts immunoradiotherapy response in advanced pretreated soft-tissue sarcoma: phase 2 trial results

Abstract Immunoradiotherapy holds promise for improving outcomes in patients with advanced solid tumors, including in soft-tissue sarcoma (STS). However, the ideal combination of treatment modalities remains to be determined, and reliable biomarkers to predict which patients will benefit are lacking...

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Main Authors: Antonin Levy, Daphné Morel, Matthieu Texier, Maria E. Rodriguez-Ruiz, Lisa Bouarroudj, Fanny Bouquet, Alberto Bustillos, Clément Quevrin, Céline Clémenson, Michele Mondini, Lydia Meziani, Roger Sun, Nadia Zaghdoud, Lambros Tselikas, Tarek Assi, Matthieu Faron, Charles Honoré, Carine Ngo, Benjamin Verret, Cécile Le Péchoux, Axel Le Cesne, Florent Ginhoux, Christophe Massard, Rastilav Bahleda, Eric Deutsch
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02173-3
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https://doi.org/10.1038/s41392-025-02173-3

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