Design and experimental validation of a new radiolabeled analog of N-(3-hydroxy-4-methoxy-phenyl-methyl) ferrocene-carboxamide (VFC) targeting the TRPV1 receptor

Design and experimental validation of a new radiolabeled analog of N-(3-hydroxy-4-methoxy-phenyl-methyl) ferrocene-carboxamide (VFC) targeting the TRPV1 receptor

The TRPV1 receptor has been recognized to play a role in cancer development, being overexpressed in prostate, breast, lung, and colon cancers. Since TRPV1 activation promotes cancer cell proliferation, invasion, and migration, TRPV1 antagonists may show potential as anti-cancer agents. Capsaicin and...

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Bibliographic Details
Main Authors: Tesnim Dallegi, Syrine Ben Hassen, Nedra Rached, Farah Menjji, Roufaida Abassi, Ameur Cherif, Soumaya Kouidhi, Mouldi Saidi, Amor Mosbah
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Molecular docking
TRPV1 receptor
Capsaicin analogs
99m-technetium
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417424000542
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