Anti-TNF-α antisense-oligonucleotide-conjugated PLG nanoparticles protect transplanted islets

Anti-TNF-α antisense-oligonucleotide-conjugated PLG nanoparticles protect transplanted islets

One of the many challenges for islet transplantation as a treatment for type 1 diabetes is inflammation that contributes to islet de-differentiation and death. Innate immune cells such as monocytes and macrophages secrete tumor necrosis factor alpha (TNF-α), interleukin 1β (IL-1β), inducible nitric...

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Bibliographic Details
Main Authors: Elizabeth J. Bealer, Namit Padgaonkar, Kelly Crumley, Eiji Saito, Zoe Beekman, Alexa DeKorte, Thazha P. Prakash, Alexey Revenko, Lonnie D. Shea
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
antisense oligonucleotide
TNF-α
SC islets
inflammation
cell transplant
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125000841
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