Single nucleus RNA-seq reveals the process from onset to chronic kidney disease in IgA nephropathy

Single nucleus RNA-seq reveals the process from onset to chronic kidney disease in IgA nephropathy

Abstract IgA nephropathy (IgAN) is a common form of glomerulonephritis. According to the established multi-hit theory of IgAN pathogenesis, the final hit is the mesangial deposition of IgA1-containing immune complexes, leading to characteristic pathological features such as mesangial cell proliferat...

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Bibliographic Details
Main Authors: Jun-Peng You, Gen-Yang Cheng, Xiao-Xue Zhang, Zheng Wang, Chen Liu, Wei Ning, Ya-Ru Liu, Hui-Miao Hu, Ya-Ling Zhai, Yuan-Yuan Qi, Zhan-Zheng Zhao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
IgA nephropathy
Single nucleus RNA-seq
Mesenchymal stromal cells
Mesangial cells
Myofibroblasts
Chronic kidney disease
Online Access:https://doi.org/10.1038/s41598-025-04292-x
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https://doi.org/10.1038/s41598-025-04292-x

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