Local–regional therapy combined with immune checkpoint inhibitors and lenvatinib versus immune checkpoint inhibitors plus chemotherapy in advanced intrahepatic cholangiocarcinoma: a multicenter cohort study

Local–regional therapy combined with immune checkpoint inhibitors and lenvatinib versus immune checkpoint inhibitors plus chemotherapy in advanced intrahepatic cholangiocarcinoma: a multicenter cohort study

Abstract Background Chemotherapy combined with immune checkpoint inhibitors (ICIs) remains the first-line treatment for advanced intrahepatic cholangiocarcinoma (ICC) but is limited by suboptimal efficacy. While local–regional therapy plus ICIs and lenvatinib (triple therapy) has demonstrated antitu...

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Main Authors: Shuofeng Li, Guanhua Yu, Mingming Wang, Shi Feng, An Zhang, Yu Wu, Zixiang Zhou, Shanshan Wang, Yihong Zhang, Mingjian Piao, Chengjie Li, Ziyu Xun, Boyu Sun, Jiongyuan Li, Nan Zhang, Hu Li, Yongliang Sun, Wen Zhang, Zhenyu Zhu, Haitao Zhao
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Biliary tract cancer
Intrahepatic cholangiocarcinoma
Local–regional therapy
Chemotherapy
Immunotherapy
Targeted therapy
Online Access:https://doi.org/10.1007/s00262-025-04129-6
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https://doi.org/10.1007/s00262-025-04129-6

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