Improved Efficacy of Triple‐Negative Breast Cancer Immunotherapy via Hydrogel‐Based Co‐Delivery of CAR‐T Cells and Mitophagy Agonist

Improved Efficacy of Triple‐Negative Breast Cancer Immunotherapy via Hydrogel‐Based Co‐Delivery of CAR‐T Cells and Mitophagy Agonist

Abstract Leaky and structurally abnormal blood vessels and increased pressure in the tumor interstitium reduce the infiltration of CAR‐T cells in solid tumors, including triple‐negative breast cancer (TNBC). Furthermore, high burden of tumor cells may cause reduction of infiltrating CAR‐T cells and...

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Bibliographic Details
Main Authors: Guodong Li, Ruoxin Du, Donghui Wang, Xiangmei Zhang, Lizhuo Wang, Shuangpeng Pu, Xiaoju Li, Shuning Wang, Juliang Zhang, Beichen Liu, Yuan Gao, Huadong Zhao
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
CAR‐T‐cell therapy
hydrogel co‐delivery
mitophagy agonist
single cell sequencing
TNBC
Online Access:https://doi.org/10.1002/advs.202409835
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https://doi.org/10.1002/advs.202409835

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