IGFBP5 mediates the therapeutic effect of isoliquiritigenin in myocardial ischemia-reperfusion injury via AKT/GLUT4 regulated insulin resistance

IGFBP5 mediates the therapeutic effect of isoliquiritigenin in myocardial ischemia-reperfusion injury via AKT/GLUT4 regulated insulin resistance

BackgroundMyocardial ischemia/reperfusion injury (MIRI) is a critical problem in cardiovascular medicine, often occurring after coronary revascularization procedures or cardiopulmonary bypass. The characters of MIRI are both energy metabolism disturbances and severe myocardium insulin resistance (IR...

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Main Authors: Jue Bai, Si-Yuan Yang, Shao-Mei Yu, Ying Cao, Chang-Han Ma, Xuan-Yi Hu, Xiong Chen, Ying-Nan Song, Hong-Jin Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
IGFBP5
isoliquiritigenin
myocardial ischemia/reperfusion injury
insulin resistance
GLUT4
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1544869/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1544869/full

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