A laminin α4–CD8+ T cell axis shapes the prognostic impact of macrophages and regulatory T cells in early-stage colorectal cancer

A laminin α4–CD8+ T cell axis shapes the prognostic impact of macrophages and regulatory T cells in early-stage colorectal cancer

The crossing of the endothelial basement membranes (BMs) is a limiting step for leukocyte diapedesis. Heterotrimeric laminins (LMs) containing α4- and α5-chains are major BM components with opposite effects on transendothelial migration. Here, we examined whether LMα4 levels influence intratumor acc...

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Bibliographic Details
Main Authors: Elena Nonnast, María Jesús Fernández-Aceñero, Tirso Pons, María Pilar Díaz Suárez, Carlos Óscar S. Sorzano, Emilia Mira, Santos Mañes
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
leukocyte
T cell
myeloid cell
transmigration
diapedesis
immunosurveillance
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2546181
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https://www.tandfonline.com/doi/10.1080/2162402X.2025.2546181

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