Microglia-targeting nanosystems that cooperatively deliver Chinese herbal ingredients alleviate behavioral and cognitive deficits in Alzheimer’s disease model mice

Microglia-targeting nanosystems that cooperatively deliver Chinese herbal ingredients alleviate behavioral and cognitive deficits in Alzheimer’s disease model mice

Abstract The effective treatment of Alzheimer’s disease (AD) is challenging because of its complex and controversial pathological mechanisms. Moreover, multiple barriers, such as the blood–brain barrier (BBB), reduce drug delivery efficiency. Microglia-related neuroinflammation has recently attracte...

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Main Authors: Peng Zhou, Quan Chao, Chen Li, Ningjing Wang, Siqi Guo, Pingping Wang, Pingyuan Ge, Caihong Li, Rui Guo, Nianyun Yang, Zhangdi Lu, Zhishu Tang, Qichun Zhang, Tingming Fu, Qingqing Xiao, Huaxu Zhu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Nanobiotechnology
Subjects:
Targeting nanosystems
Chinese herbal medicines
Alzheimer’s disease
Neuroinflammation
Microglia phenotype
Online Access:https://doi.org/10.1186/s12951-025-03385-z
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https://doi.org/10.1186/s12951-025-03385-z

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