Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents
Abstract Natural products are the important sources in cardiovascular drug development. In this study, twenty-nine buthutin derivatives were designed, synthesized, and evaluated for their NHE-1 inhibition and protective effects on cardiomyocyte injury. The structure of the newly synthesized compound...
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Main Authors: | Yuan Liu, Fa-Qi Wang, Xin-Hao Hua, Shu-Han Yang, Li-Ning Wang, Yun-Sheng Xu, Chen-Yue Shao, Xiang-Bo Gou, Yu-Ming Liu |
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Format: | Article |
Language: | English |
Published: |
SpringerOpen
2025-02-01
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Series: | Natural Products and Bioprospecting |
Subjects: | |
Online Access: | https://doi.org/10.1007/s13659-025-00497-9 |
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