Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents

Abstract Natural products are the important sources in cardiovascular drug development. In this study, twenty-nine buthutin derivatives were designed, synthesized, and evaluated for their NHE-1 inhibition and protective effects on cardiomyocyte injury. The structure of the newly synthesized compound...

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Bibliographic Details
Main Authors: Yuan Liu, Fa-Qi Wang, Xin-Hao Hua, Shu-Han Yang, Li-Ning Wang, Yun-Sheng Xu, Chen-Yue Shao, Xiang-Bo Gou, Yu-Ming Liu
Format: Article
Language:English
Published: SpringerOpen 2025-02-01
Series:Natural Products and Bioprospecting
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Online Access:https://doi.org/10.1007/s13659-025-00497-9
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