The Pharmacological Evidences for the Involvement of AhR and GPR35 Receptors in Kynurenic Acid-Mediated Cytokine and Chemokine Secretion by THP-1-Derived Macrophages

The Pharmacological Evidences for the Involvement of AhR and GPR35 Receptors in Kynurenic Acid-Mediated Cytokine and Chemokine Secretion by THP-1-Derived Macrophages

Kynurenic acid (KYNA), a tryptophan metabolite, possesses immunomodulatory properties, although the molecular mechanism of this action has not yet been resolved. In the present study, the effects of KYNA on the secretion of selected cytokines and chemokines by macrophages derived from the human THP-...

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Bibliographic Details
Main Authors: Katarzyna Sawa-Wejksza, Jolanta Parada-Turska, Waldemar Turski
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Molecules
Subjects:
kynurenic acid
THP-1
macrophages
aryl hydrocarbon receptor
G protein-coupled receptor 35
cytokines
Online Access:https://www.mdpi.com/1420-3049/30/15/3133
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