Cell-cell communication-mediated cell-type-specific parent-of-origin effects in mammals

Cell-cell communication-mediated cell-type-specific parent-of-origin effects in mammals

Abstract Genomic imprinting is manifested as monoallelic expression of genes according to parental origin, which is closely linked to mammalian placentation and human diseases. Yet, it is unclear how genomic imprinting evolves in different cell types. Here we generate a single-nucleus transcriptomic...

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Main Authors: Jia-Jin Wu, Enqin Zheng, Langqing Liu, Jianping Quan, Donglin Ruan, Zekai Yao, Jifei Yang, Xuehua Li, Shiyuan Wang, Ming Yang, Zebin Zhang, Meng Lin, Zheng Xu, Zicong Li, Gengyuan Cai, Jie Yang, Zhenfang Wu
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60469-y
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https://doi.org/10.1038/s41467-025-60469-y

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