Regulation of Th1/Th2 cells in asthma development: A mathematical model
Airway exposure levels of lipopolysaccharide (LPS) determine type I versus type IIhelper T cell induced experimental asthma. While high LPS levels induce Th1-dominantresponses, low LPS levels derive Th2 cell inducedasthma. The present paper develops a mathematical model of asthma development which...
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| Format: | Article |
| Language: | English |
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AIMS Press
2013-05-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.1095 |
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| author | Yangjin Kim Seongwon Lee You-Sun Kim Sean Lawler Yong Song Gho Yoon-Keun Kim Hyung Ju Hwang |
| author_facet | Yangjin Kim Seongwon Lee You-Sun Kim Sean Lawler Yong Song Gho Yoon-Keun Kim Hyung Ju Hwang |
| author_sort | Yangjin Kim |
| collection | DOAJ |
| description | Airway exposure levels of lipopolysaccharide (LPS) determine type I versus type IIhelper T cell induced experimental asthma. While high LPS levels induce Th1-dominantresponses, low LPS levels derive Th2 cell inducedasthma. The present paper develops a mathematical model of asthma development whichfocuses on the relative balance of Th1 and Th2 cell induced asthma. In the present workwe representthe complex network of interactions between cells and molecules by a mathematical model.The model describes the behaviors of cells (Th0, Th1, Th2 and macrophages)and regulatory molecules (IFN-$\gamma$, IL-4, IL-12, TNF-α) in response tohigh, intermediate, and low levels of LPS.The simulations show howvariations in the levels of injected LPSaffect the development ofTh1 or Th2 cell responses through differential cytokine induction.The model also predicts the coexistence ofthese two types of responseunder certain biochemical and biomechanical conditions in the microenvironment. |
| format | Article |
| id | doaj-art-9eb2b543b25a4c0986136c25c2f848eb |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2013-05-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-9eb2b543b25a4c0986136c25c2f848eb2025-01-24T02:26:20ZengAIMS PressMathematical Biosciences and Engineering1551-00182013-05-011041095113310.3934/mbe.2013.10.1095Regulation of Th1/Th2 cells in asthma development: A mathematical modelYangjin Kim0Seongwon Lee1You-Sun Kim2Sean Lawler3Yong Song Gho4Yoon-Keun Kim5Hyung Ju Hwang6Department of Mathematics, Konkuk University, SeoulDepartment of Mathematics, Konkuk University, SeoulDepartment of Mathematics, Konkuk University, SeoulDepartment of Mathematics, Konkuk University, SeoulDepartment of Mathematics, Konkuk University, SeoulDepartment of Mathematics, Konkuk University, SeoulDepartment of Mathematics, Konkuk University, SeoulAirway exposure levels of lipopolysaccharide (LPS) determine type I versus type IIhelper T cell induced experimental asthma. While high LPS levels induce Th1-dominantresponses, low LPS levels derive Th2 cell inducedasthma. The present paper develops a mathematical model of asthma development whichfocuses on the relative balance of Th1 and Th2 cell induced asthma. In the present workwe representthe complex network of interactions between cells and molecules by a mathematical model.The model describes the behaviors of cells (Th0, Th1, Th2 and macrophages)and regulatory molecules (IFN-$\gamma$, IL-4, IL-12, TNF-α) in response tohigh, intermediate, and low levels of LPS.The simulations show howvariations in the levels of injected LPSaffect the development ofTh1 or Th2 cell responses through differential cytokine induction.The model also predicts the coexistence ofthese two types of responseunder certain biochemical and biomechanical conditions in the microenvironment.https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.1095th1/th2 cellslpsasthmamicroenvironmentinflammation. |
| spellingShingle | Yangjin Kim Seongwon Lee You-Sun Kim Sean Lawler Yong Song Gho Yoon-Keun Kim Hyung Ju Hwang Regulation of Th1/Th2 cells in asthma development: A mathematical model Mathematical Biosciences and Engineering th1/th2 cells lps asthma microenvironment inflammation. |
| title | Regulation of Th1/Th2 cells in asthma development: A mathematical model |
| title_full | Regulation of Th1/Th2 cells in asthma development: A mathematical model |
| title_fullStr | Regulation of Th1/Th2 cells in asthma development: A mathematical model |
| title_full_unstemmed | Regulation of Th1/Th2 cells in asthma development: A mathematical model |
| title_short | Regulation of Th1/Th2 cells in asthma development: A mathematical model |
| title_sort | regulation of th1 th2 cells in asthma development a mathematical model |
| topic | th1/th2 cells lps asthma microenvironment inflammation. |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2013.10.1095 |
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