ER-endosome contacts generate a local environment promoting phagophore formation

ER-endosome contacts generate a local environment promoting phagophore formation

Summary: Autophagy starts with the formation of a double-membrane vacuole called the autophagosome, initiated by a transient structure known as the phagophore. Previous studies reported that phagophore biogenesis primarily occurs at endoplasmic reticulum (ER) omegasome subdomains, but other evidence...

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Main Authors: Juliane Da Graça, Charlotte Thiola, Myckaëla Rouabah, Ida Chiara Guerrera, Naïma El Khallouki, Maryse Romao, Carla Alemany, Dobrawa Amiri, Sarah Dubois, Ashvini Srimoorthy, Francesca Giordano, Graça Raposo, Etienne Morel
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
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CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007648
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