Dexmedetomidine promotes colorectal cancer progression mediated by gamma-aminobutyric acid signaling

Abstract Objective Cancer cells exhibit abnormal dependence on glutamine, which is associated with the hyperactivation of γ-aminobutyric acid (GABA) metabolic pathways that promotes tumor growth. The α2-adrenergic receptor agonist dexmedetomidine (DEX) has been reported to promote colorectal cancers...

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Bibliographic Details
Main Authors: Jing Dong, Yuanyuan Wu, Ji Che, Zhiyong He, Jun Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cancer & Metabolism
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Online Access:https://doi.org/10.1186/s40170-025-00403-4
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