2, 2′, 4, 4′-tetrabromodiphenyl ether induces thyroid toxicity by targeting BRAF-mediated MEK-ERK-NIS pathway in human thyroid follicular epithelial cells

2, 2′, 4, 4′-tetrabromodiphenyl ether induces thyroid toxicity by targeting BRAF-mediated MEK-ERK-NIS pathway in human thyroid follicular epithelial cells

2, 2’, 4, 4’-tetrabromodiphenyl ether (BDE-47), one of the most abundant and toxic congeners of polybrominated diphenyl ethers (PBDEs), has been implicated in thyroid disorders, but its thyroid toxicity in human thyroid cells and underlying mechanisms remain unclear. Given the pivotal role of the V-...

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Bibliographic Details
Main Authors: Guangshan Xie, Jinping Lu, Jiayi Song, Jianqing Zhang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
BDE-47
Thyroid toxicity
BRAF
MEK-ERK signaling pathway
Human thyroid cell
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325009224
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