The sigma‐1 receptor‐TAMM41 axis modulates neuroinflammation and attenuates memory impairment during the latent period of epileptogenesis

The sigma‐1 receptor‐TAMM41 axis modulates neuroinflammation and attenuates memory impairment during the latent period of epileptogenesis

Abstract Background Therapy in the latent period is favorable for retarding the process of epileptogenesis. Recently, we have discovered that the activated sigma‐1 receptor (Sig‐1R) attenuates the hippocampus pathological injury and memory impairment in the latent period of epileptogenesis. But the...

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Bibliographic Details
Main Authors: Jianlun Ji, Ce Gao, Qinghua Wang, Xiaoxia Jia, Hao Tian, Yaqin Wei, Zhidong Liu, Yun Wang, Lin Guo
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Animal Models and Experimental Medicine
Subjects:
epileptogenesis
memory impairment
mitochondrial translocator assembly and maintenance 41 homolog
neuroinflammation
sigma‐1 receptor
Online Access:https://doi.org/10.1002/ame2.12341
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https://doi.org/10.1002/ame2.12341

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