Twist1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of Twist1

Twist1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of Twist1

Non-small cell lung carcinoma (NSCLC) is a major cause of cancer mortality. High expression of the epithelial-to-mesenchymal transition transcription factor (EMT-TF) Twist1 is strongly associated with metastatic cancers and with treatment resistance. Twist1 can also upregulate O-GlcNAcylation to sup...

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Main Authors: Audrey Lafargue, Hailun Wang, Sivarajan T. Chettiar, Rajendra P. Gajula, Amol C. Shetty, Yang Song, Brian W. Simons, Muhammad Ajmal Khan, Triet Nguyen, Hwai-Wei Tseng, Jinhee Chang, Danielle N. Waters, Aaron Chan, Christine Lam, Francesca A. Carrieri, Caleb Smack, Nick Connis, Dipanwita Dutta Chowdhury, Katriana Nugent, Ismaeel Siddiqui, Kekoa Taparra, Mohammad Rezaee, Natasha Zachara, Zachary S. Morris, Christopher McFarland, Sarki Abba Abdulkadir, Christine L. Hann, Phuoc T. Tran
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
TWIST1
Oncogene-Induced Senescence
Non-Small Cell Lung Cancer
GEMM
MYC
O-GlcNAcylation
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000582
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