Spectrophotometric Estimation of Abacavir Sulphate in Pharmaceutical Formulations
Two simple, accurate, rapid and sensitive methods (A and B) have been developed for the estimation of abacavir sulphate in its pharmaceutical dosage form. The method A and B are based on the formation of chloroform extractable complex of abacavir sulphate with bromophenol blue (method A) and bromocr...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/764602 |
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| author | N. Appala Raju J. Venkateswara Rao K. Vanitha Prakash K. Mukkanti |
| author_facet | N. Appala Raju J. Venkateswara Rao K. Vanitha Prakash K. Mukkanti |
| author_sort | N. Appala Raju |
| collection | DOAJ |
| description | Two simple, accurate, rapid and sensitive methods (A and B) have been developed for the estimation of abacavir sulphate in its pharmaceutical dosage form. The method A and B are based on the formation of chloroform extractable complex of abacavir sulphate with bromophenol blue (method A) and bromocresol green (method B), which shows absorbance maxima at 460 nm and 469 nm respectively. The absorbance-concentration plot is linear over the range of 1-10 mcg/mL for method A and B respectively. Results of analysis for all the methods were validated statistically and by recovery studies. The proposed methods are economical and sensitive for the estimation of abacavir sulphate in bulk drug and in its tablet dosage form. |
| format | Article |
| id | doaj-art-9e71f385a09348ceaccc0a406974f67d |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-9e71f385a09348ceaccc0a406974f67d2025-02-03T01:09:36ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-015351151410.1155/2008/764602Spectrophotometric Estimation of Abacavir Sulphate in Pharmaceutical FormulationsN. Appala Raju0J. Venkateswara Rao1K. Vanitha Prakash2K. Mukkanti3Department of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road No. 3, Banjara Hills, Hyderabad-500 034, IndiaDepartment of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road No. 3, Banjara Hills, Hyderabad-500 034, IndiaDepartment of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy, Mount Pleasant, Road No. 3, Banjara Hills, Hyderabad-500 034, IndiaInstitute of Science and Technology, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad -500072, IndiaTwo simple, accurate, rapid and sensitive methods (A and B) have been developed for the estimation of abacavir sulphate in its pharmaceutical dosage form. The method A and B are based on the formation of chloroform extractable complex of abacavir sulphate with bromophenol blue (method A) and bromocresol green (method B), which shows absorbance maxima at 460 nm and 469 nm respectively. The absorbance-concentration plot is linear over the range of 1-10 mcg/mL for method A and B respectively. Results of analysis for all the methods were validated statistically and by recovery studies. The proposed methods are economical and sensitive for the estimation of abacavir sulphate in bulk drug and in its tablet dosage form.http://dx.doi.org/10.1155/2008/764602 |
| spellingShingle | N. Appala Raju J. Venkateswara Rao K. Vanitha Prakash K. Mukkanti Spectrophotometric Estimation of Abacavir Sulphate in Pharmaceutical Formulations E-Journal of Chemistry |
| title | Spectrophotometric Estimation of Abacavir Sulphate in Pharmaceutical Formulations |
| title_full | Spectrophotometric Estimation of Abacavir Sulphate in Pharmaceutical Formulations |
| title_fullStr | Spectrophotometric Estimation of Abacavir Sulphate in Pharmaceutical Formulations |
| title_full_unstemmed | Spectrophotometric Estimation of Abacavir Sulphate in Pharmaceutical Formulations |
| title_short | Spectrophotometric Estimation of Abacavir Sulphate in Pharmaceutical Formulations |
| title_sort | spectrophotometric estimation of abacavir sulphate in pharmaceutical formulations |
| url | http://dx.doi.org/10.1155/2008/764602 |
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